{"id":47386,"date":"2025-01-06T09:16:21","date_gmt":"2025-01-06T13:16:21","guid":{"rendered":"https:\/\/www.thebeertimes.com\/?p=47386"},"modified":"2026-07-01T17:48:01","modified_gmt":"2026-07-01T21:48:01","slug":"how-alcohol-alters-brain-reward-system-dopamine","status":"publish","type":"post","link":"https:\/\/www.thebeertimes.com\/en\/how-alcohol-alters-brain-reward-system-dopamine\/","title":{"rendered":"How Does Alcohol Alter the Brain&#8217;s Reward System? The Importance of Dopamine"},"content":{"rendered":"<div id=\"thebe-3997380917\" class=\"thebe-antes-del-contenido-3 thebe-entity-placement\">\n            <div \n                class=\"elfsight-widget-popup elfsight-widget\" \n                data-elfsight-popup-options=\"%7B%22blocks%22%3A%5B%7B%22id%22%3A%22babc7e96-e195-4da3-a8c5-7072d42f2f5c%22%2C%22type%22%3A%22image%22%2C%22imageFile%22%3A%7B%22type%22%3A%22uploaded%22%2C%22data%22%3A%7B%22name%22%3A%2261d71zGp0%2BL._SL1500_%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.thebeertimes.com%5C%2Fwp-content%5C%2Fuploads%5C%2F2026%5C%2F02%5C%2F61d71zGp0L._SL1500_.jpg%22%2C%22size%22%3A45654%2C%22type%22%3A%22image%22%2C%22extension%22%3A%22jpeg%22%2C%22width%22%3A940%2C%22height%22%3A1500%2C%22ext%22%3A%22jpeg%22%7D%7D%2C%22imageScale%22%3A60%7D%2C%7B%22id%22%3A%226689e0da-ab1d-42a0-ac83-457ff13f91dd%22%2C%22type%22%3A%22button%22%2C%22buttonText%22%3A%22Buy%20on%20AMAZON%22%2C%22buttonAction%22%3A%22redirect%22%2C%22buttonStyle%22%3A%22filled%22%2C%22buttonShape%22%3A%22rectangle%22%2C%22buttonColor%22%3A%22rgb%28255%2C%2038%2C%2067%29%22%2C%22buttonFontSize%22%3A16%2C%22label%22%3A%22Button%22%2C%22buttonUrl%22%3A%22https%3A%5C%2F%5C%2Fwww.amazon.com%5C%2Fdp%5C%2FB0GDGJJWD2%22%7D%5D%2C%22layout%22%3A%22modal%22%2C%22width%22%3A500%2C%22popupBlocksAlignment%22%3A%22center%22%2C%22popupShape%22%3A%22rounded%22%2C%22popupBackgroundColor%22%3A%22rgb%28255%2C%20255%2C%20255%29%22%2C%22popupBackgroundImage%22%3Anull%2C%22popupBackgroundImageOverlayColor%22%3A%22%22%2C%22overlayVisible%22%3Atrue%2C%22overlayClose%22%3Atrue%2C%22overlayBackgroundColor%22%3A%22rgba%2817%2C%2017%2C%2017%2C%200.7%29%22%2C%22overlayBackgroundImage%22%3Anull%2C%22overlayBackgroundImageOverlayColor%22%3A%22%22%2C%22closeButtonVisible%22%3Atrue%2C%22closeButtonColor%22%3A%22rgba%2817%2C%2017%2C%2017%2C%200.7%29%22%2C%22triggerPageLoadEnabled%22%3Afalse%2C%22triggerTimeOnPageEnabled%22%3Afalse%2C%22triggerTimeOnPageDuration%22%3A30%2C%22triggerScrollEnabled%22%3Atrue%2C%22triggerScrollPosition%22%3A25%2C%22triggerScrollToElementEnabled%22%3Afalse%2C%22triggerScrollToElementId%22%3Anull%2C%22triggerClickEnabled%22%3Afalse%2C%22triggerClickElementId%22%3Anull%2C%22triggerExitIntentEnabled%22%3Afalse%2C%22displayFrequency%22%3A%22everytime%22%2C%22displayPages%22%3A%22allPages%22%2C%22displayExcludedPages%22%3A%5B%5D%2C%22displaySpecificPages%22%3A%5B%5D%2C%22displayDevices%22%3A%5B%22desktop%22%2C%22tablet%22%2C%22mobile%22%5D%2C%22widgetId%22%3A%224%22%7D\" \n                data-elfsight-popup-version=\"1.0.0\"\n                data-elfsight-widget-id=\"elfsight-popup-4\">\n            <\/div>\n            <\/div><div id=\"thebe-2045579363\" class=\"thebe-fuente-preferida-2 thebe-entity-placement\" style=\"margin-bottom: 30px;margin-left: auto;margin-right: auto;text-align: center;\"><a href=\"https:\/\/www.google.com\/preferences\/source?q=thebeertimes.com\" target=\"_blank\" aria-label=\"A\u00f1adir como fuente preferida en google\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2026\/07\/Anadir-como-fuente-preferida-en-google-1.jpg\" alt=\"\"  srcset=\"https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2026\/07\/Anadir-como-fuente-preferida-en-google-1.jpg 638w, https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2026\/07\/Anadir-como-fuente-preferida-en-google-1-300x60.jpg 300w\" sizes=\"(max-width: 638px) 100vw, 638px\" width=\"175\" height=\"127\"  style=\"display: inline-block;\" \/><\/a><\/div><p>The interaction between alcohol and dopamine is a complex neurological phenomenon that not only explains the immediate effects of alcohol consumption, but also sheds light on the underlying mechanisms of addiction and mood disorders.<\/p>\n<figure id=\"attachment_34589\" aria-describedby=\"caption-attachment-34589\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-34589 size-full\" title=\"Alcohol and dopamine\" src=\"https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2025\/01\/Alcohol-y-dopamina.jpeg\" alt=\"Alcohol and dopamine\" width=\"600\" height=\"315\" srcset=\"https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2025\/01\/Alcohol-y-dopamina.jpeg 600w, https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2025\/01\/Alcohol-y-dopamina-300x158.jpeg 300w, https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2025\/01\/Alcohol-y-dopamina-114x60.jpeg 114w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-34589\" class=\"wp-caption-text\">Alcohol and dopamine<\/figcaption><\/figure><div id=\"thebe-3633199238\" class=\"thebe-maridaje-sin-rodes thebe-entity-placement\" style=\"margin-left: auto;margin-right: auto;text-align: center;\"><div style=\"background-color: #ffffff; border: 1px solid #ccc; border-radius: 12px; padding: 16px; max-width: 320px; margin: 20px auto; text-align: center; font-family: helvetica, arial, sans-serif;\">\n<p><a href=\"https:\/\/amzn.to\/3YnM2eX\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-45298 aligncenter\" src=\"https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2026\/01\/maridaje-188x300.jpg\" alt=\"\" width=\"125\" height=\"200\" srcset=\"https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2026\/01\/maridaje-188x300.jpg 188w, https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2026\/01\/maridaje.jpg 313w\" sizes=\"auto, (max-width: 125px) 100vw, 125px\" \/><\/a><\/p>\n<p style=\"color: #0000ff; font-weight: bold; margin: 8px 0; line-height: 1.2;\"><a href=\"https:\/\/amzn.to\/3YnM2eX\" target=\"_blank\" rel=\"nofollow\"><span style=\"font-size: 11pt;\">Maridaje de cerveza y comida sin rodeos. Un enfoque directo para quienes consumen, sirven y venden cerveza<\/span><\/a><\/p>\n<p><a class=\"fasc-button fasc-size-medium fasc-type-flat fasc-rounded-medium fasc-ico-before dashicons-cart\" style=\"background-color: #ff9900; color: #000000;\" target=\"_blank\" rel=\"nofollow\" href=\"https:\/\/amzn.to\/3YnM2eX\">Comprar en Amazon<\/a><\/p>\n<\/div>\n<\/div>\n<p>Exploring this interaction from a neurochemical and behavioral perspective helps us better understand how alcohol modulates the brain&#8217;s reward system and what implications this has for mental and physical health.<\/p>\n<div id=\"thebe-1716185528\" style=\"margin-bottom: 30px;\"><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-9395258998211551\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display:block;\" data-ad-client=\"ca-pub-9395258998211551\" \ndata-ad-slot=\"8775458773\" \ndata-ad-format=\"auto\"><\/ins>\n<script> \n(adsbygoogle = window.adsbygoogle || []).push({}); \n<\/script>\n<\/div>\n<h2>Dopamine and the reward system<\/h2>\n<p>Dopamine is a key neurotransmitter in the brain&#8217;s reward system, a neural circuit that reinforces behaviors essential for survival, such as eating or socializing.<\/p>\n<p>When alcohol enters the body, its ability to rapidly cross the blood-brain barrier allows it to interact with this system almost immediately.<\/p>\n<blockquote>\n<p>The blood-brain barrier is a specialized barrier that lines the blood vessels of the brain. Its primary function is to protect the central nervous system by regulating the passage of substances, allowing essential nutrients to enter while blocking toxins and pathogens.<\/p>\n<\/blockquote>\n<p>The nucleus accumbens, a critical region in the reward circuit, is particularly sensitive to the effects of alcohol.<\/p>\n<p>This initial surge in dopamine creates a feeling of pleasure and euphoria, which reinforces the behavior of consumption.<\/p>\n<p>However, this interaction is not direct. Alcohol does not activate dopaminergic neurons in a primary way, but rather does so through indirect mechanisms.<\/p>\n<p>For example, by enhancing the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, alcohol reduces the activity of neurons that normally suppress the release of dopamine.<\/p>\n<blockquote>\n<p>An inhibitory neurotransmitter is a molecule that reduces neuronal activity by making it harder to generate electrical signals. Its function is to balance the brain, prevent overstimulation, and modulate processes such as relaxation and sleep.<\/p>\n<\/blockquote>\n<p>This paradoxical effect results in an increase in dopamine in the nucleus accumbens.<\/p>\n<p>In addition, alcohol stimulates the release of endogenous opioids, such as endorphins, which in turn activate dopaminergic pathways.<\/p>\n<p>These combined mechanisms explain why alcohol consumption can be so gratifying in the short term.<\/p>\n<h2>Short-term pleasure and disinhibition<\/h2>\n<p>In the early stages of consumption, the increase in dopamine produces notable behavioral and emotional effects.<\/p>\n<p>The feeling of well-being and euphoria is one of the most evident, but a reduction in social anxiety and an increase in sociability are also observed.<\/p>\n<p>These effects may explain why alcohol is frequently used as a &#8220;social lubricant.&#8221;<\/p>\n<p>However, this behavioral disinhibition can also lead to risky behaviors, such as driving under the influence or making impulsive decisions.<\/p>\n<p>It is important to note that these effects are not uniform across all individuals. Factors such as genetics, consumption history, and prior emotional state can influence the intensity of the dopaminergic response.<\/p>\n<p>As Koob and Le Moal (2008) note in their theory of addiction, individual variability in reward system sensitivity may predispose some people to develop dependence more easily than others.<\/p>\n<h2>Long-term adaptation and dysregulation<\/h2>\n<p>Chronic alcohol consumption leads to a series of neurochemical adaptations with profound implications.<\/p>\n<p>One of the most significant is the desensitization of the dopaminergic system.<\/p>\n<blockquote>\n<p>The dopaminergic system is a network of neurons that produce and release dopamine, a key neurotransmitter in the regulation of functions such as pleasure, motivation, movement, and cognition.<\/p>\n<\/blockquote>\n<p>Over time, the brain reduces the number of dopamine receptors in response to elevated levels of this neurotransmitter.<\/p>\n<p>This phenomenon, known as downregulation, means that more alcohol is required to achieve the same level of pleasure that was previously obtained with smaller amounts.<\/p>\n<p>This is a central mechanism in the development of tolerance and, subsequently, dependence.<\/p>\n<p>In addition, prolonged alcohol consumption can disrupt the balance of the reward system.<\/p><div id=\"thebe-2662913634\" class=\"thebe-libros-amazon thebe-entity-placement\" style=\"margin-left: auto;margin-right: auto;text-align: center;\"><div style=\"background-color: #ffffff; border: 1px solid #ccc; border-radius: 12px; padding: 16px; max-width: 320px; margin: 20px auto; text-align: center; font-family: helvetica, arial, sans-serif;\">\n<p><a href=\"https:\/\/amzn.to\/3LddZmQ\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-43340 aligncenter\" src=\"https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2025\/05\/Catar-cerveza-300x300.jpg\" alt=\"Gu\u00eda Pr\u00e1ctica Catar Cerveza Amazon\" width=\"200\" height=\"199\" srcset=\"https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2025\/05\/Catar-cerveza-300x300.jpg 300w, https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2025\/05\/Catar-cerveza-150x150.jpg 150w, https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2025\/05\/Catar-cerveza-370x370.jpg 370w, https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2025\/05\/Catar-cerveza.jpg 500w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><\/p>\n<p style=\"color: #0000ff; font-weight: bold; margin: 8px 0; line-height: 1.2;\"><a href=\"https:\/\/amzn.to\/3LddZmQ\" target=\"_blank\" rel=\"nofollow\"><span style=\"font-size: 11pt;\">Gu\u00eda pr\u00e1ctica para catar cerveza: C\u00f3mo apreciar correctamente todas las cervezas del mundo<\/span><\/a><\/p>\n<p><a class=\"fasc-button fasc-size-medium fasc-type-flat fasc-rounded-medium fasc-ico-before dashicons-cart\" style=\"background-color: #ff9900; color: #000000;\" target=\"_blank\" rel=\"nofollow\" href=\"https:\/\/amzn.to\/3LddZmQ\">Comprar en Amazon<\/a><\/p>\n<\/div>\n<\/div>\n<p>The brain begins to associate alcohol with reward, which reinforces the behavior of consumption and impairs the ability to experience pleasure through other activities.<\/p>\n<p>This phenomenon, known as &#8220;hijacking&#8221; of the reward system, is a key characteristic of addiction (Volkow et al., 2016).<\/p>\n<p>During periods of abstinence, baseline dopamine levels can fall significantly, contributing to symptoms such as anhedonia, depression, and anxiety.<\/p>\n<p>These neurochemical changes not only perpetuate the cycle of consumption, but also increase the risk of mood disorders.<\/p>\n<h2>Risks and clinical considerations<\/h2>\n<p>The interaction between alcohol and dopamine has implications not only for addiction, but also for mental and cognitive health.<\/p>\n<p>Dysregulation of the dopaminergic system can contribute to the development of disorders such as depression and anxiety, which often coexist with alcoholism.<\/p>\n<p>In addition, the neurological damage caused by chronic consumption can affect cognitive functions such as memory, attention, and decision-making.<\/p>\n<p>From a clinical perspective, understanding this interaction has been fundamental to the development of pharmacological treatments.<\/p>\n<p>For example, drugs that modulate the dopaminergic system, such as dopamine receptor antagonists, have been used to reduce cravings and aid in recovery.<\/p>\n<p>However, as Nutt et al. (2015) note, treating alcoholism requires a multifaceted approach that includes behavioral therapy and psychological support, since addiction is not only a neurochemical problem, but also a behavioral and social one.<\/p>\n<div id=\"thebe-1118670130\" style=\"margin-bottom: 20px;margin-left: auto;margin-right: auto;text-align: center;\"><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-9395258998211551\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display:block; text-align:center;\" data-ad-client=\"ca-pub-9395258998211551\" \ndata-ad-slot=\"1179889612\" \ndata-ad-layout=\"in-article\"\ndata-ad-format=\"fluid\"><\/ins>\n<script> \n(adsbygoogle = window.adsbygoogle || []).push({}); \n<\/script>\n<\/div>\n<h2>Final reflections<\/h2>\n<p>The interaction between alcohol and dopamine is a paradigmatic example of how substances can alter brain chemistry and modulate behavior.<\/p>\n<p>While the immediate effects may be gratifying, the long-term consequences can be devastating.<\/p>\n<p>Understanding these mechanisms is not only crucial for preventing and treating addiction, but also for developing more effective interventions that address both the neurochemical and behavioral aspects of alcohol consumption.<\/p>\n<p>Ultimately, this knowledge reinforces the importance of moderation or abstinence in alcohol consumption, especially in individuals with a predisposition to dependence or mood disorders.<\/p>\n<p>As a society, it is essential to continue researching and educating on these topics to reduce the impact of alcohol on public health.<\/p>\n<div id=\"thebe-2105742243\" style=\"margin-bottom: 30px;\"><div id=\"pf-15242-1\" data-format=\"display\" ><script>window.pubfuturetag = window.pubfuturetag || [];window.pubfuturetag.push({unit: \"683988d268662b3361d8a48f\", id: \"pf-15242-1\"})<\/script><\/div><\/div>\n<p><script type=\"application\/ld+json\">\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How long does it take the brain to recover its dopamine levels after quitting alcohol?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"The neurochemical restoration process varies depending on the duration and intensity of use, but in general, baseline dopamine levels begin to stabilize between 3 and 12 months of complete abstinence. During the first months, it is common to experience 'prolonged withdrawal syndrome' (anhedonia and apathy), as the brain needs time to upregulate its damaged dopaminergic receptors.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Are there natural supplements to increase dopamine after drinking alcohol?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Although no supplement fully reverses the damage, dopamine precursors such as L-tyrosine and L-theanine, or adaptogenic plants such as Mucuna pruriens and Rhodiola rosea, are frequently sought to mitigate the mood dip the day after drinking (hangover). However, neurologists note that the most effective way to restore the neurotransmitter is through deep rest, physical exercise, and a diet rich in high-quality protein.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Why doesn't coffee or caffeine eliminate the effect of alcohol on the brain?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"It is a common myth to think that coffee sobers up a drunk person. While alcohol depresses the nervous system and indirectly alters dopamine, caffeine is a stimulant that blocks adenosine receptors. When mixed, coffee only masks drowsiness, creating a state of wide-awake drunkenness that is highly dangerous, as the person feels falsely sober, but their reflexes, judgment, and coordination remain severely impaired.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is the relationship between genetic dopamine deficit (ADHD) and alcoholism?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"People with ADHD naturally present dysregulation or deficiency in dopamine transmission. This causes them to seek immediate stimulation. Clinical studies have shown that individuals with ADHD have a significantly higher risk of developing alcohol addiction, as they use the substance as a form of unconscious self-medication to artificially elevate their dopamine levels and calm their cerebral restlessness.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Does alcohol consumption affect dopamine in the same way in men and women?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"No. Neurobiological research suggests that women experience the neurotoxic effects and reward system dysregulation faster and at lower doses of alcohol than men (a phenomenon clinically known as telescoping). This is due to metabolic differences, lower body water percentage, and the interaction of hormonal fluctuations (such as estrogen), which modulate brain sensitivity to dopamine and accelerate the transition from social use to dependence.\"\n      }\n    }\n  ]\n}\n<\/script><\/p>\n<h2>Frequently asked questions (FAQ)<\/h2>\n<h3>1. How long does it take the brain to recover its dopamine levels after quitting alcohol?<\/h3>\n<p>The neurochemical restoration process varies depending on the duration and intensity of use, but in general, baseline dopamine levels begin to stabilize between 3 and 12 months of complete abstinence. During the first months, it is common to experience &#8220;prolonged withdrawal syndrome&#8221; (anhedonia and apathy), as the brain needs time to upregulate its damaged dopaminergic receptors.<\/p>\n<h3>2. Are there natural supplements to increase dopamine after drinking alcohol?<\/h3>\n<p>Although no supplement fully reverses the damage, dopamine precursors such as L-tyrosine and L-theanine, or adaptogenic plants such as Mucuna pruriens and Rhodiola rosea, are frequently sought to mitigate the mood dip the day after drinking (hangover). However, neurologists note that the most effective way to restore the neurotransmitter is through deep rest, physical exercise, and a diet rich in high-quality protein.<\/p>\n<h3>3. Why doesn&#8217;t coffee or caffeine eliminate the effect of alcohol on the brain?<\/h3>\n<p>It is a common myth to think that coffee &#8220;sobers up&#8221; a drunk person. While alcohol depresses the nervous system and indirectly alters dopamine, caffeine is a stimulant that blocks adenosine receptors. When mixed, coffee only masks drowsiness, creating a state of &#8220;wide-awake drunkenness&#8221; that is highly dangerous, as the person feels falsely sober, but their reflexes, judgment, and coordination remain severely impaired.<\/p>\n<h3>4. What is the relationship between genetic dopamine deficit (ADHD) and alcoholism?<\/h3>\n<p>People with ADHD naturally present dysregulation or deficiency in dopamine transmission. This causes them to seek immediate stimulation. Clinical studies have shown that individuals with ADHD have a significantly higher risk of developing alcohol addiction, as they use the substance as a form of unconscious &#8220;self-medication&#8221; to artificially elevate their dopamine levels and calm their cerebral restlessness.<\/p>\n<h3>5. Does alcohol consumption affect dopamine in the same way in men and women?<\/h3>\n<p>No. Neurobiological research suggests that women experience the neurotoxic effects and reward system dysregulation faster and at lower doses of alcohol than men (a phenomenon clinically known as telescoping). This is due to metabolic differences, lower body water percentage, and the interaction of hormonal fluctuations (such as estrogen), which modulate brain sensitivity to dopamine and accelerate the transition from social use to dependence.<\/p>\n<h2>References<\/h2>\n<p>1. Koob, G. F., &amp; Le Moal, M. (2008). <em>Neurobiology of Addiction<\/em>. Academic Press.<\/p>\n<p>2. Volkow, N. D., Wise, R. A., &amp; Baler, R. (2016). The dopamine motive system: implications for drug and food addiction. <em>Nature Reviews Neuroscience, 18<\/em> (12), 741-752. <a href=\"https:\/\/doi.org\/10.1038\/nrn.2017.130\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1038\/nrn.2017.130<\/a><\/p>\n<p>3. Nutt, D. J., Lingford-Hughes, A., Erritzoe, D., &amp; Stokes, P. R. (2015). The dopamine theory of addiction: 40 years of highs and lows. <em>Nature Reviews Neuroscience, 16<\/em> (5), 305-312. <a href=\"https:\/\/doi.org\/10.1038\/nrn3939\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1038\/nrn3939<\/a><\/p>\n<div id=\"thebe-4016566296\" class=\"thebe-maridaje-cerveza-marihuana thebe-entity-placement\" style=\"margin-bottom: 40px;\"><div style=\"background-color: #ffffff; border: 1px solid #ccc; border-radius: 12px; padding: 16px; max-width: 320px; margin: 20px auto; text-align: center; font-family: helvetica, arial, sans-serif;\">\n<p><a href=\"https:\/\/www.amazon.com\/dp\/B0GF4CFJBL\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-45353\" src=\"https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2026\/01\/71vKJFxJDRL._SL1500_-187x300.jpg\" alt=\"\" width=\"125\" height=\"200\" srcset=\"https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2026\/01\/71vKJFxJDRL._SL1500_-187x300.jpg 187w, https:\/\/www.thebeertimes.com\/wp-content\/uploads\/2026\/01\/71vKJFxJDRL._SL1500_.jpg 312w\" sizes=\"auto, (max-width: 125px) 100vw, 125px\" \/><\/a><\/p>\n<p style=\"color: #0000ff; font-weight: bold; margin: 8px 0; line-height: 1.2;\"><a href=\"https:\/\/www.amazon.com\/dp\/B0GF4CFJBL\" target=\"_blank\" rel=\"nofollow\"><span style=\"font-size: 11pt;\">Maridaje profesional de cerveza y marihuana. 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